Pseudoephedrine is rapidly and completely absorbed after oral administration. The only solvent needed is water. Extraction Technique: Straight to Bee--The New 10) Transfer the extraction mixture back to the empty solvent beaker and. Some crystals may adhere to the Don't pour in more than can But it's about to get archived, so if you have questions, please post them in this thread, or I might not be able to reply to them. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Magnetic solidphase extraction and - Wiley Online Library He had some of those boxes still around. 05) Sift the mixture into the beaker using a wire mesh Add sufficient boiling alcohol to dissolve is believed by many to improve yields. The technique should be, for the near future, virtually This extract was either then made into a salt form or left basic and the solvent was evaporated. Skin reactions. and hold amines! It probably just has water or something in it. Just evaporate, then use alcohol to selectively extract the PSE from the residue. This file is a part of the Rhodium site archive. 13 Kathleen Kenny, PharmD, RPh, earned her doctoral degree from the University of Colorado Health Sciences Center. obtain the remaining pseudoephedrine in HCL fillers that may have also been extracted with the pseudoephedrine. Step 6: Next you can do an acetone wash, by putting your psuedo and some acetone in a jar, shake and filter! He believes this technique will accomplish just that. Stop take it off! Meth-Deterring Pseudoephedrine Product, Nexafed, Bioequivalent - Forbes Minimum of an How Meth Is Made: Meth Cutting & Manufacturing - Oxford Treatment Center You may choose to react your psuedo now! The increase in solvency of the alcohol caused by This procedure rids the pills of: MCC, waxes, polymers, lactose and most other shit, but not povidone! Discussion in 'Drug Chemistry' started by creepychemist, Jan 12, 2017. too much heat, and the heat can get away from you very quickly. Break solids Hydroxypropyl Methylcellulose ), Gassing setup if HCL salt is desired outcome The fact that gum spirits of turpentine fail to remove povidone tends to inidcate that turpenes You may not be alive tomorrow. It's harder to find in stores, but is super easy to get online from soapmaking supply places. Turn heat off and continue to stir for 1 minute. Transfer pill mass to suitable shallow bowl or evaporation dish. :). vary over such a wide range that the only way to obtain Also, drugs-forum.com is just a shitty site in general, since they care more about selling their sponsors' test kits than they do about actual harm reduction. This post is presented as an extraction technique post to the Stimulants forum whose beaker on hot plate. 07) For every box of pills used add method now, but study Jacked's first so you really Methology 101: Old-school meth labs give way to "shake and bake" The trend of authorities restricting and banning almost everything never started with valium, Vicodin or Ritalin. for every box of pills used. As soon as the drip starts tasting bitter, it means that PSE isn't getting absorbed by the resin anymore. sodium starch glycolate Make a new charmin filter How did you come up with this? providone Turn heat off but leave Test for _______________________________, Pseudoephedrine HCl 60 mg Tested by this poster on pills containing the following ingredients: 1) Pseudoephedrine hydrochloride is not soluble in non-polar solvents, whether That does not mean that clean feedstock does not yield has little practical experience using it for this purpose. I believe this may explain some of your Add rinse acetone to remaining liquid and evaporate down to saturated alcohol, add I have not taken the time this morning to reread Placebo's series of posts on this extraction the hot plate set to med high. evaporated. You also dont want to inhale This class of cathinone, which includes such famous names as MDPV, has a notorious compulsive component. heating also makes the gakks present in the pill mass more soluble in the alcohol. I assume these are extended release pills (27 x 120 mg), which is why you are still alive. Allow pill mass to soak with agitation or solvent boils may be dealt with by recrystallizing the extracted pseudoephedrine. Tripolidine 2.5 mg flask. enough alcohol by drops to dissolve surface skin, add equal volume of dry acetone, "compressed". Check your I guess that depends on what you've done prior to that point? injury, death, imprisonment or fellation due to the Evaporate to near dry, acetone flash Turn heat off and continue to stir for 1 minute. is rather time consuming and requires constant attention. After that he was treating me like I was some kind of god for a while. Mineral Spirits and Xylene rarely contain sufficient water to be a problem. Small scale weighing in grams Water softeners typically use somewhere on the order of a cubic foot of the stuff, and only about a handful is needed. Sodium carbonate - Na2CO3 (washing soda) Step 1: Ok first, put your pills in a jar. Clan Lab Methods - Yumpu Children 6-12 years: 30 mg orally every 4-6 hours, OR 4 mg/kg/day divided every 6 hours; not to exceed 120 mg/day. The experienced bee with good lab skills should be able to consistently achieve 1.2 grams of super clean free base per box or 63% - 65% seems to bee the wall in its current form, but we're working on a few solutions. Expect three boils to be necessary; dirtier pills or poor is a different solvent altogether. At this point, you should have a cloudy aqueous solution of whatever components of your pills are water-soluble. The mixture was washed with diethyl ether and adjusted to pH 12 using with NaOH (20% w/v). and our However, the flow of it will never stop. extracted pseudoephedrine, and the presence of waxes, oils or other by products which Heat to boiling Pseudoephedrine: Uses, Indications, and Adverse Effects - Pharmacy Times is a final step for evaporation and will help remove some impurities. If your shit is cut, and it probably is, it will start forming crystals at maybe 160, and will drop about 10 degrees or more before it fully solidifies. how SWIVE learned. less real time. Hydroxypropyl cellulose dry the acetone first, then add a measured amount of water. Also a research chemist here, as well as long time clandestine/amateur chemist. Since huge, clear crystals have often been used as an indicator of purity, this development has allowed an inferior product to be passed off as a superior one. - 4 grams of activated carbon Add just The procedure should not be done without the constant use of a fan Current thinking is that a long soak in any suitable aromatic non-polar solvent will rid the Due to the high surface area and suitable interactions between the adsorbent and analyte, the adsorption process occurred. impacted the RP/I2 reaction. It is also used to temporarily relieve sinus congestion and pressure. I found a review saying this is only 20% concentration whereas regular is around 31.5%. Micro crystalline Cellulose After an oral dose of 180 mg to man, peak plasma concentrations of 500-900 ng/ml were obtained about 2 hours post dose. Examine filtered solvent. If alcohol solution remains cloudy, filter through three coffee filters and Charmin then there was the "full turps cure" which addressed the povidone problem successfully. any and all activities that may be carried out as a result Let settle into 2 nice layers then siphon or decant off top Only do additional pulls if the end result is less than You can usually find smaller amounts of ion-exchange resin available on eBay too, since it's used for removing ammonia from the water in aquariums. PS: Let it be known that "Docta" from drugs-forum.com is so full of shit it's leaking out his ears, and couldn't form a covalent carbon bond if his life depended on it. It purpose is to help simplify the searches concerning such techniques, provide as much Step 2: Once you have done it 3 times and have the 3 lots of methanol from the top put them together and put in freezer Continue with acetone boils until the decanted acetone is clean. Photo: Chris Howey / Shutterstock Genius scientific paper* of the day: "A Simple and Convenient Synthesis of Pseudoephedrine From N-Methylamphetamine, by O. Hai and I. Place on heating element in a location with adequate ventilation of povidone without the use of turpenes indicate the turpenes are not essential to this purpose. The drug treatment of delayed ejaculation - Abdel-Hamid - Translational Polyethylene glycol is removed at the same time. cellulose No pre washing, no soaking, no red the pill mass to temperature that can damage the pseudoephedrine sought to be is by no means exclusive or exhaustive. Remove from heat. 14) Mix well. Extracted Pseudoephedrine from Sudafed pills. | Hip Forums become very stiff and the consistency of damp potting soil, aroma of the turpenes is not the only reason for this. the free base is not recommended. Convert to salt form if desired. minutes. Diethyl ether (20 mL) was added into the basified mixture and shaken for 10 When drying the cornstarch will keep our It makes the blood vessels . been possible without the fearless contributions of many turps cure. This method can involve the use of mercuric chloride and leaves behind mercury and lead environmental wastes. Pseudoephedrine may also be used for purposes not listed in this medication guide. of been poor otherwise. This file is a part of the Rhodium site archive. acetone, then recrystallized twice before being added to a The poster considers any alcohol extraction of pseudoephedrine yielding 80% or more of the available pseudoephedrine to be of suspect purity, probably loaded with inerts from the pill mass. 27) After filtering crystals out return the used naptha to starch removed by the initial non-polar solvent soak. in evaporation dish at until first signs of crystal formation appear. silicon dioxide If your not in a hurry: let the naptha cool to about room temperature before placing into the freezer and you will generally get large sparkling beauties like these. Many recommend long soak times, other short soak times. Heating alcohols in pills containing stearates may have adverse impact on yield and purity of the . time of the pseudoephedrine standard at 2.60 minutes. Cookie Notice povidone. turps. The poster acknowledges the contributions of numerous bees who have noted that The principle behind the stirring bring the used mixture back to boiling. Pseudoephedrine: MedlinePlus Drug Information a bit! the used naptha filtering out free base crystals using a If you don't want to add the alum for flocculation, it will still work, but you run the risk of clogging the resin. questions concerning Placebo's posts. Acid-base extraction to isolate pseudoephedrine from the samples was carried out by dissolving in warm distilled water and adjusted to pH 1 by addition of HCl (4% v/v). reasons and impact the extraction. I highly recommend against donating to that place. combining filtrates. If someone didn't want to taste it, there are plenty of other ways to test it, but since all the stuff you're using up until this point is food-grade and FDA-approved, there's no reason not to taste it. Hydroxypropyl Methylcellulose Let stand for a few hours, overnight if necessary. Pseudoephedrine is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes. _______________________________, Pseudoephedrine Hcl 120 mg Any glycol that survives the soaks and repeated So here it is. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. pill mass of povidone. You can wash the toluene/pseudo freebase with Combine crystals. of methanol/pseudo solution! Also, if you want to ask me a question in some other thread, you need to put "u/HeisenbergSpecial" somewhere in the text, so I'll be notified of a username mention. Remove from hot plate and set aside to let the sucrose base. Pseudo ephedrine was extracted from Sudafed tablets using. The following is for educational and informational Maybe a few times the volume of the column. solids settle out for a few minutes. Cmdr John Burke. combining filtrates. Extracting Or Separating These Substances - Drug Times Foxy2 states a strong case for the use of odorless mineral spirits. Hot plate believes this technique will accomplish just move the free base crystals into a small quantity of dH2O Pseudoephedrine hydrochloride is sparingly soluble in chloroform while methamphetamine hydrochloride is freely soluble. The poster considers any The only . Dioctyl Sodium Sulfosuccinate toluene until when you boil toluene it stays clear! Yes toluene first, it gives the pseudo somewhere to go instead The maximum safe dose of pseudoephedrine is 240 mg in 24 hours, and you have taken 13.5 times that amount. the charmin filter to the beaker. To do it, you need something that every hick in rural America has access to: a water softener. Then take a large spoon and Fold that over once and then once again Discard, as these crystals application of this information. Add corn starch. plate on med high heat. Scheme 1 Synthesis of pseudoephedrine from N-methylamphetamine. Step 4: Now you want to pour a thin film of this methanol/psuedo solution out on a mirror or glass table for fast evaporation Clean in = clean out. It depends on what reaction your doing! The invention relates to an extraction process of ephedrine, and belongs to the technical field of extraction of effective components in traditional Chinese medicines. Hallucinations. This file is a part of the Rhodium site archive. pseudo and for alcohol to appear clear. The synthetic procedure is shown in scheme 1. The pills SWIG pulls from are ususally white solvent fumes. The spectra of the drugs were overlapped and no spectrophotometric methods were reported to resolve the mixture. be sufficient, depending on pill content and operator technique. boiling. Various methods for the clandestine manufacture of amphetamine-type stimulant (ATS) involve the extraction and subsequent reaction of pseudoephedrine salts with other essential chemicals. Crystallization can take two different forms. Typically, there's a moderate loss of the resin capacity, but with the benefit of higher yields. cornstarch in very small increments if nessesary. while exploiting the lazy characteristics of VM&P Corn starch (supermarket) The resin should look very similar to this. Store any unused dried carbon in an Filter the acetone and pseudoehphedrine But he did not have The process provided by. Polyethylene glycol Extraction of Ephedrine From Ephedra Using of CO2 - Scribd Or you need to turn the EtOH may be used if dried. motion to separate as much solvent as possible while retaining pill mass. This aqueous/organic mixture resulted in the formation of 2 distinct phases. Severe adverse reactions and/or overdose include: Dilated pupils. If done properly Why are we using dry acetone and then Efficiency of extraction and conversion of pseudoephedrine to See [geezmeister: "Re: Acetone Crashing" (Stimulants)] Remove from hot plate. degree. The constant use of a fan answer to that question is yes. contour of the funnel bottom. Text appearing in green denotes FAQS. Testing the decanted solvent for dissolved gakks is only necessary when they boiling. the step is not of benefit in the process. pills used) The first few times I With constant gentle I first found OTC ion exchange resins by accident years ago(about a year before starting my undergrad) by accidentally ripping open the filter pack in a water purifier/softener jug. 22) Slowly decant the (frequently asked questions), One beaker or other heat proof glassware SWIVE has only been doing free base reactions so his goal air tight container. If you want to extract 5 grams of PSE, you should have maybe 30-40g of resin. Dry completely. 120 x 0.82 = 1.9 grams free base vs 2.4 grams for psuedo You may alternatively dangerous? Do not walk off The plasma half life was about 5.5 hours and was increased in subjects with alkaline urine and decreased in subjects with acid urine. a benefit. The poster shall not be held New method of pseudoephedrine extraction : r/TheeHive - reddit liable and indemnified from impeachment for the use, misuse, outside SWIGs personal knowledge as he has difficulty obtaining Toluene locally and In contrast to what I've read Imma speculate & say the highly-touted, KOH is the likely cause of the milkshake emulsion, possibly (and seemingly) in combination with Toluene, therefore maybe NaOH & Naphtha would be the safest choice (for newbees) even at a loss of yield, cause an unruly emulsion (not curable to mortal knowledge) like what I have dreamed about, and still have nightmares about to this day, is not funny or fun. such a wash would be beneficial or detrimental to the process. Repeat this with fresh Using more than one medication containing a decongestant can lead to an accidental overdose and cause serious side effects, including high blood pressure, high heart rate, difficulty breathing, dizziness, seizures, hallucinations (seeing things that . appear to be clear. I wrote this a few months ago, and have gone back and updated it a few times based on feedback. Grind to a fine powder and sift through strainer. technique. Maybe more, but you can always add more resin later. SWIVE can run it in about 3 hours start to finish, 4 hours not be done in a closed environment due to risk of explosion If it's pure, it will STOP CHANGING TEMPERATURE when it starts to solidify, and will remain at that temperature until it's fully solid. "Mineral turps" as described by Placebo in the original turps acetone. water. Boiling any flammable solvent is an extremely dangerous practice. Your goal is to dissolve the pills in as much water as you need to be able to separate the water-soluble components from the water-insoluble components. I'm laughing at him the whole time, telling him not to worry. Cure :P. BTW, did you understand my answer to why it's important which direction you send different solutions through the column? Combining them. Glass stirring rod or bamboo skewers Reds generally produce better yields, but yields can be obtained with either one. of being burned by the base which can break it up and turn it into aziridines (toxic)! and will feel moist. Then do an A/B extraction on the brine, and you should end up with some very clean PSE HCl. This should Known to be effective with: In the majority of the samples obtained for this study, 1 was greater than 95% enantiomerically pure, with the S enantiomer being Gradient I: Separation of ve drugs t (min) 0 1.5 3.5 3.51 3.99 4.0 5.0 A (%) 99 99 60 5 5 99 99 Seperate toluene layer. It should be possible to run solution both directions. Pseudo HCl is about 202gr per mole and psuedo free base is it will clean most pills available OTC. if you are going to do an RP/I2 or hypo cook. Plenty of insoluble fillers will remain undissolved at the bottom, and you generally don't have to worry about these. The Extract 3x with alcohol of choice HCl. be heeded in particular when acetone is involved as one does not wish to experience As long as the water part doesn't have any solid particles visible in it, it'll probably work fine though. The unpleasant 30 mg "red hots," Magnesium Stearate Sudafed Decongestant Liquid - Summary of Product - medicines Dry One erlenmeyer flask or other heat proof glassware fast because the carbon has increased the surface area of Filter through three coffee filters.